The fact that mRNA COVID-19 vaccines are not contaminated with excessive or dangerous levels of residual DNA should not really have to be addressed. Nonetheless, doing so often comes up in arguments to debunk what is becoming a persistent trope of the anti-vaccine lobby.

In November last year I looked at an excellent report from Australia’s Therapeutic Goods Administration (TGA), which plainly called the claim, misinformation. In March this year refuting the myth of “Turbo Cancer”, I went through a bunch of already well debunked attempts to justify the existence of this non-existent cancer. DNA contamination of COVID mRNA vaccines took up a few paragraphs.

The popularity of residual DNA contamination as a cause of invented harms favoured by anti-vaccine fear mongers shouldn’t surprise us. We received easy to understand information from health authorities well before the COVID vaccine rollout, that mRNA in vaccines never penetrates the cell nucleus and thus, DNA would remain untouched. Yet that very notion was targeted early and often by contrarians. Then came the flawed science with flawed methodology, that still remains unpublished. Remember the testing of vials that arrived anonymously in the mail without cold packs? Don’t forget mRNA vaccines require storage at about -20ºC. Then came sleight of hand by Kevin McKernan et al, using Qubit Fluorometric Quantification (fluorometry) in an unwarranted addition to the original testing regime of Quantitative PCR (qPCR). qPCR indicated DNA below FDA guidelines. Fluorometry significantly and inaccurately inflates results because it measures mRNA when calculating total DNA levels.

In fact there’s a few elements to understanding why DNA in mRNA vaccines is a non-event. That’s why I recommend watching Dr. Dan Wilson of Debunk the Funk on YouTube. Dan’s been flattening bogus bumps in the anti-vaccine world for quite a while now. His video on 2 July called Update on DNA contamination is one of a few he’s done tackling this particular myth. Interestingly, what recently caught my eye was Dan’s praise for the TGA report on misinformation about excessive DNA in mRNA vaccines.

Dan wrote to the TGA to check how they determine COVID DNA in their samples, as there are various ways to do this (see video 7:15). It turns out the TGA used the method that “most over-estimates the amount of DNA that could possibly be in that vial”. This still yielded “zero batches that exceeded the limit of residual DNA”.

So again, what this tells us is that DNA contamination of mRNA vaccines is a total furphy and they remain completely safe. Still, I sincerely recommend spending 10 minutes checking out Dan’s video, and having a look through his others for sound information to educate yourself about persistent and evolving anti-vaccine disinformation and misinformation.