SIDS: Not caused by vaccination or ‘mattress toxin’

From a typical anti-vaccine site pushing vaccine injuries:

SIDS_and_pertussis

These figures do not confirm causality. See explanation below ♣

One claim the anti-vaccine lobby use in their attack against the efficacy of the pertussis vaccine is the high uptake rate. The logic being that with high uptake and proper vaccine efficacy, pertussis should be better controlled than it is. In fact completely controlled. Thus the pertussis vaccine is a failure.

Whilst the vaccine may not provide impervious protection, infection of those vaccinated is much less common and markedly less severe.

And those not vaccinated against pertussis? According to Immunise Australia:

In a household where someone has whooping cough, an estimated 80-90% of the unimmunised contacts of that person will acquire the disease.

These realities won’t shift committed antivaccinationists. They will be convinced by the terribly misleading claim above, using unrelated figures on SIDS and pertussis vaccination. I find it astonishing anyone could be swayed by it. Yet for readers unskilled in finding reputable information or not prone to checking alarming claims it has an intuitive ring of causality.

♣ Infants receive vaccine doses at two, four and six months of age. 90% of SIDS cases occur in the first six months of life, and most of these in the first three months. The risk decreases consistently. After twelve months babies are by definition not infants and the risk of Sudden Unexplained Death is significantly reduced.

So the claim above merely sounds plausible because infants are most at risk of SIDS up to six months. Over this time they have three pertussis vaccines. The vast majority of children in developed nations will follow the pertussis vaccination schedule.

SIDS and Kids is an Australian organisation that supports educating the public about the “significantly” reduced risk of SIDS that accompanies immunisation. They have also noted that when the age of first immunisation was lowered by four weeks there was no lowering of the average age of SIDS.

SIDS and kids

SIDS_ImmunisationsDownload the full SIDS and Kids PDF Information Statement – Immunisation

German research published in Vaccine in 2007 indicates that immunisation notably reduces the risk of SIDS. Vennemann et al concluded in Do immunisations reduce the risk of SIDS? A meta-analysis (bold mine):

Immunisations are associated with a halving of the risk of SIDS. There are biological reasons why this association may be causal, but other factors, such as the healthy vaccine effect, may be important. Immunisations should be part of the SIDS prevention campaigns.

A constant assertion from the anti-vaccine lobby is that of “too many, too soon”, contending that modern vaccine schedules overwhelm infants and children in a manner yet to be uncovered. An earlier study by Vennemann et al, Sudden infant death syndrome: No increased risk after immunisation found no evidence for this but rather the opposite.

  • Results:

SIDS cases were immunised less frequently and later than controls. Furthermore there was no increased risk of SIDS in the 14 days following immunisation. There was no evidence to suggest the recently introduced hexavalent vaccines were associated with an increased risk of SIDS.

  • Conclusion:

This study provides further support that immunisations may reduce the risk of SIDS.

A number of studies have been conducted in Australasia, North America and Europe. All confirm that immunisation is not causally linked to SIDS. Thus early immunisation is coincidental to the age at which SIDS is most likely. In fact the reverse is true with respect to causality. SIDS cases are less likely to be immunised or fully immunised. Unlike most “vaccine injuries” this favourite fear tactic of antivaccinationists does have an origin in a published report.

The CDC Morbidity and Mortality Weekly Report 1979; 28: 131-132 noted in DTP vaccination and sudden infant deaths – Tennessee that four babies had died within 24 hours of being immunised. The following Weekly Report clarifies (pp. 134-135) under Follow-up on DTP vaccination and sudden infant deaths – Tennessee:

Further examination of the vaccination histories of infants who died suddenly has revealed no additional instances of vaccination within 24 hours before death.
Thus, 4 deaths have been found that occurred within 24 hours after receipt of vaccine from Lot No. 64201, compared with no deaths within 24 hours after DTP vaccination in the earlier 8-month period in Tennessee.
In 1991 The Institute of Medicine published a thorough examination of this matter. Item 5 of Adverse Effects of Pertussis and Rubella Vaccines: A Report of the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines, is Evidence Concerning Pertussis Vaccines and Deaths Classified as SIDS. The article reviews the initial CDC Weekly Report along with 38 other reports and research papers spanning the 12 year interval. The summary includes:
All controlled studies that have compared immunized versus nonimmunized children (Table 5-1) have found either no association (Bouvier-Colle et al., 1989; Pollock et al., 1984; Taylor and Emery, 1982) or a decreased risk (Hoffman et al., 1987; Walker et al., 1987) of SIDS among immunized children.
[…]
One small controlled study of infants with unexplained apnea, who may be at increased risk for SIDS, demonstrated improvement in ventilatory patterns following DPT immunization (Keens et al., 1985).
  • Conclusion

The evidence does not indicate a causal relation between DPT vaccine and SIDS. Studies showing a temporal relation between these events are consistent with the expected occurrence of SIDS over the age range in which DPT immunization typically occurs.

It’s important to note that at this stage no research demonstrating a reduction in SIDS due to immunisation had been published. Consequently the authors do not mention this effect.

In 1995 E.A. Mitchell et al examined the association between immunisation and SIDS. They observed there is no increased risk of SIDS following the Hepatitis B immunisation or the 6 week DTP immunisation. They also noted early studies suggesting an increased risk of SIDS with immunisation had no control data. Two studies with controls that suggested such a temporal link demonstrated methodological bias.

Mitchell et al concluded:

Immunisation does not increase the risk of SIDS and may even lower the risk.

Jacqueline Muller-Nordhorn et el published Association between SIDS and DTP immunisation: an ecological study [10.1186/s12887-015-0318-7]. The aim was to analyse this association over time. The body of the paper’s Discussion included;

  • SIDS mortality rates have been inversely associated with DTP immunisation coverage in the United States over recent decades
  • The most notable decreases in SIDS rates occurred from 1991 onwards, coinciding with increases in DTP immunisation
  • In 2011, the Task Force on Sudden Infant Death Syndrome included immunisation as one of the recommendations to reduce the risk of SIDS [Citation]
  • However, recommendations to the public and the ‘grey literaure’ often do not include immunisation in the prevention of SIDS. Prevailing safety concerns with regard to immunisation may have played a role in this hesistance for many years
  • DTP immunisation may protect against SIDS by preventing infection with Bordetella (B.) pertussis. SIDS might thus be undiagnosed pertussis
  • In approximately 50–80% of SIDS cases, signs of upper and lower respiratory tract infection, characterised by a mild cellular infiltrate, have been found
  • Furthermore, similar to DTP immunisation, OPV immunisation was associated with a reduced risk of SIDS. Case–control studies have associated a similar reduction in SIDS risk with DTP and OPV immunisation, whereas less evidence is available regarding Hib immunisation
  • In addition to the pertussis component, DTP includes diphtheria and tetanus components. Certain countries, such as England and Sweden, previously experienced major decreases in pertussis immunisation but administered diphtheria and tetanus vaccines separately, thus maintaining high coverage
  • The SIDS trends in these countries were similar to the trends in the United States. Thus, diphtheria and tetanus immunisation seem less likely to be associated with SIDS

They concluded:

DTP immunisation is inversely associated with SIDS mortality on the population level. The current findings may strengthen parents’ confidence in the benefit of DTP immunisation, especially as they are supported by the results of two meta-analyses*.

*See Vennemann et al, above.

October 2010 saw the Scientific consensus forum to review the evidence underpinning the recommendations of the Australian SIDS and Kids Safe Sleeping Health Promotion Programme [PDF]. This Position Paper is published in the Journal of Paediatrics and Child Health [doi:10.1111/j.1440-1754.2011.02215.x]

SIDSandKids_key points

The document is an excellent publication covering the evidence and recommendations that apply to reducing SIDS. On page three the topic of Immunisation is addressed:

Parents are advised to immunise their babies according to the national vaccination schedule. The possibility of the DTP (diphtheria-tetanus-pertussis) vaccination being linked to SIDS has been discussed periodically over the last 20 years, however a series of studies have consistently refuted the association. A recent meta-analysis published provides strong evidence that immunisation is associated with a decreased risk of SIDS (OR 0.54; 95% CI = 0.39–0.76).

We should note that the delightfully immoral antivactionist and author of Melanie’s Marvellous Measles, Stephanie Messenger was involved in peddling a long debunked “prevention” for SIDS. In fact SIDS and Kids have their own evidence based and comprehensive publication outlining why mattress wrapping offers no protection. A March 2003 article in Pediatric and Developmental Pathology, SIDS: Overview and Update offers evidence to debunk both the “mattress toxin” myth and proposed links to immunisation (p. 121).

In 1989 in the UK Barry Richardson contended that the fungus Scopularis brevicaulis broke down fire retardant chemicals in mattresses or their PVC covers. This produced arsine, phosphine and stibine gases from antimony, phosphorous and arsenic. A UK study failed to replicate Richardson’s findings. A follow up study with Richardson’s collaboration also failed to duplicate the proposed findings.

I highly recommend reading the SIDS and Kids information sheet on this pseudoscientific mess and the conspiracy hovering over it. In May 1998 an Expert Group to Investigate Cot Death Theories: Toxic Gas Hypothesis, UK examined all available evidence and found:

…there is no evidence to suggest that antimony or phosphorus containing compound used as fire retardant in PVC and other cot mattress materials are a cause of sudden infant death syndrome.

This conclusion is based upon the following:

  1. Cot mattress contamination with the fungus S. brevicalis is rare, and no more common in SIDS mattresses than in other used mattresses.
  2. There is no evidence for the generation of gases from phosphorus, arsenic and antimony from cot mattresses, by S. brevecaulis, when tested using conditions relevant to a baby’s cot. (the group did, however, identify laboratory conditions, wholly unlike those that could occur in a baby’s cot, in which added antimony is biovolatilised, but to the much less toxic trimethylantimony and not to stibine).
  3. There is no evidence of poisoning by phosphine, arsine, or stibine (or bethylated derivatives) in babies who have died of SIDS.
  4. Low amounts of antimony can be detected in samples from the majority of live babies, and even newborn babies: the concentrations in the tissues of SIDS babies were not different from those dying from known causes. there are a number of sources of antimony in the domestic environment other than the fire retardant in cot mattress materials.
  5. We have found no evidence that the changing rates of sudden infant death correspond to the introduction and removal of antimony – and phosphorus – containing fire retardant in cot mattresses.

SIDS and Kids also mention the conspiracy book Cot Death Cover-up? by N.Z. forensic chemist Jim Sprott. Stephanie Messenger also mentioned this book at her secret seminars wherein she peddled her “mattress covers” to protect against SIDS. There is a fascinating February 2012 account of a conspiracy laden seminar on the Skeptimite blog. In April of this year it was reported that Messenger had the charity status of her “SIDS charity” Get Rid Of SIDS revoked.

Just as well one feels. Not only because the scam had done no charity work and employed nobody. Messenger had gone from blaming vaccination for SIDS to pushing the phoney toxic gas theory as the cause – 20 years after it was first debunked and progressively relegated to conspiracy theory. When Messenger’s plan to bring the very harmful anti-vaccine heroine Sherri Tenpenny to Australia, she then advocated readers purchase her pro-measles book to help her out of debt.

Ultimately nothing has changed with respect to the anti-vaccine claim that SIDS is caused by vaccines. In fact evidence supporting the opposite remains firm.

We may also rest assured that mattress wrapping is an evidence free, conspiracy based waste of time.

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The problem of clustered drops in herd immunity

There are many reasons anti-vaccine lobbyists push the falsehood that herd immunity “is a myth”, is not important or simply doesn’t exist.

To listen to recent untruths from Meryl Dorey, one should eagerly accept that it is “documented” in peer reviewed literature as being more or less non-existent. Indeed, “it is a lie” lies Dorey. By essentially mocking the importance of herd immunity, garden variety anti-vaccine tricksters can shirk the responsibility that not vaccinating may harm the wider community, innocent infants or children, and deny larger scale resistance to infection that the immune-compromised rely on.

Herd immunity is an impressive function of mass vaccination. More so it is remarkably easy to understand. But the anti-vaccine lobby refuse to accept any need for or benefit from, mass vaccination. It is even more bizarre when one considers the parallels to so-called “natural immunity” – such as with marvellous measles, or “right of passage” infection and immunity. With mass vaccination we can control the spread of immunity and thus the spread and ultimate impact of vaccine preventable disease.

We should never forget that claims of raising impeccably healthy and disease-free unvaccinated children can exist only for as long as vaccine-induced herd immunity remains at a crucial level. The level that permits a free ride and protection from most vaccine preventable diseases for these very children.

Once again the formula frequently relied upon is “< 100% = 0%” – such as this 1973 article. One popular mode is that if a child is vaccinated against X, they should be safe from infection with X. Even worse is a distortion of epidemiological factors at play. This involves citing nationwide or statewide vaccination rates – which level out as reasonably high – along with reported outbreaks, such as those seen of pertussis or measles. Or including individuals who have had just one MMR jab (in the case of measles) or those whose vaccine-induced pertussis immunity has certainly waned.

This not-very-clever deception ignores the fact that areas with low vaccination uptake provide the ideal conditions for infection to spread rapidly.

The video below compares the difference in infection spread in the sparsely located unvaccinated compared to a cluster of unvaccinated individuals.

Herd Immunity

Vaccines contain no aborted fetal cells

One of the most offensive lies peddled about vaccines is that they “contain aborted foetal cells”.

Consider this April 2013 screenshot from AVN Facebook:

Aborted fetal tissue

I noticed an even more absurd take when reading Anti-vaccine chiropractors redux-1, c/o reasonablehank. He was reviewing the anti-vaccine rantings of one “Dr” Koe Davidson who is a chiropractor running Peak Potential Health and Wellness in Mentone, Melbourne. One screenshot includes Davidson addressing vaccine ingredients as listed by the CDC. It includes:

Oh and “egg protein” = fancy word for aborted fetus cells. This wording was changed in mid 2012… Scary stuff.

For a document last updated in February 2012 I’m not sure what he’s trying to convey. The CDC cannot have changed egg protein to aborted “fetus” cells in 2012 as this would be complete nonsense. Thus one must conclude he is either utterly confused on the topic of cell cultures or – as is common with chiropractors aligned with the CAA – misinforming readers.

The CDC write about egg protein as a vaccine additive:

Egg protein is found in yellow fever and most influenza vaccines, which are prepared using chicken eggs. Ordinarily, persons who are able to eat eggs or egg products safely can receive these vaccines.

So how can such confusion on cell cultures come to pass? Today strains of human diploid cell culture are grown in containers in laboratories. In the manufacture of vaccines, viruses that infect humans are grown in these human diploid cell lines. One strain of human diploid cell culture was made in the USA in 1961. Labelled WI-38 this strain came from the lung tissue of an aborted female of three months gestation.

Another human diploid cell culture was produced in the UK in 1966. The tissue came from the lungs of a 14 week old male foetus and the strain is labelled MRC-5. W.I. refers to the Wistar Institute. M.R.C. refers to the Medical Research Council.

The abortions did not take place with the intent of producing human diploid cell culture for use in vaccine manufacture. The biologists who produced the diploid cultures did not induce the abortions. Both abortions were intentional and would have been carried out whether the foetal tissue had that fate or not, post abortion.

These cells used to grow viruses have been reproducing since 1961 (WI-38) and 1966 (MRC-5), respectively. The viruses produced this way are further processed and sterilised in the production of the vaccine. In this way any potential for contamination with foetal material is eliminated. Furthermore, strict quality control measures are employed to examine each vaccine to ensure no foetal material is present.

♣ The USA National Network for Immunization Information state (bold mine):

These two cell strains have been growing under laboratory conditions for more than 35 years. The cells are merely the biological system in which the viruses are grown. These cell strains do not and cannot form a complete organism and do not constitute a potential human being. The cells reproduce themselves, so there is no need to abort additional fetuses to sustain the culture supply. Viruses are collected from the diploid cell cultures and then processed further to produce the vaccine itself. ♣

Vaccines produced using WI-38 and MRC-5 human diploid cell lines include hepatitis A, rabies, rubella, MMR, varicella and Pentacell DTaP-IPV/Hib.

Another abortion was performed on a rubella virus-infected mother in 1968. Both mother and foetus were infected with wild rubella and this posed the risk of major birth defects. Foetal tissues were obtained and wild rubella virus (RA27/3) was isolated. This has been grown in human foetal diploid cell line WI-38. No foetal tissue is present in the vaccine. No further abortions are necessary to produce more vaccines.

Prior to isolation of RA27/3 the USA experienced 800 cases of congenital rubella annually. At the turn of the century only three babies with congenital rubella were born. Research was carried out to study the possibility of using other animal cells to produce the RA27/3 rubella vaccine. However these proved less effective and less safe.

The Vatican accepts the use of human diploid cells in the manufacture of vaccines. A June 9th 2005 Vatican City Statement on Aborted Fetal Vaccines acknowledges this. It notes use of these cell lines is:

…to avoid a serious risk not only for one’s own children but also, and more specifically, for the health conditions of the population as a whole – especially for pregnant women.

For example, the severe epidemic of German measles which affected a huge part of the United States in 1964 thus caused 20,000 cases of congenital rubella2, resulting in 11,250 abortions (spontaneous or surgical), 2,100 neonatal deaths, 11,600 cases of deafness, 3,580 cases of blindness, 1,800 cases of mental retardation. It was this epidemic that pushed for the development and introduction on the market of an effective vaccine against rubella, thus permitting an effective prophylaxis against this infection.

[And observes that]

…the parents who did not accept the vaccination of their own children become responsible for the malformations [due to rubella infection] in question.

Think of an apple orchard. The organic material nourishing the trees includes (say) manure, bird droppings, animal carcases, rotting vegetation and so on. If one eats an apple one is not eating manure or the carcass of an unfortunate passing mammal. To say vaccines contain cellular material is to employ exactly such flawed thinking.

A vaccine initially made using human diploid cells that passed FDA requirements via another production method is the RabAvert rabies vaccine by Chiron Corporation. When safe and effective alternatives can replace the methodology involving human diploid cells we shall begin to see them. It is a fact that the human strains are superior in many ways. However they are not, in any way shape or form, “aborted foetal cells”.

The claim that vaccines contain the cells of aborted foetuses or are contaminated with any organic material is quite simply false.

A Mother’s Choice, Fear and Confusion

In April and May 2009 channel Seven’s Sunday Night programme looked at the activities of The Australian Vaccination Network.

Following the first programme – A Mother’s Choice – the producers held a live audience forum entitled Fear and Confusion.

Both episodes are below, with a final credit scroll examining the activity of anti-vaccine GP, Giselle Cooke, which led to a NSW Medical Tribunal hearing.

Essential addition to understanding the importance of keeping up pertussis vaccination/s and not succumbing to antivax fear mongering. Remember, whilst only 5% of children are not vaccinated against pertussis they make up close to 30% of infections.

And that’s on top of being up to four times less likely to visit a conventional doctor and be diagnosed in the first place!

The LymphoSite

Before reading this post be aware that as of April 2014 we now know that Australian strains of B. pertussis have largely lost expression of the protein whose variation is a key feature of this piece. An explanation of that study can be found here.

Summary

Whooping cough is a potentially deadly infectious disease. While vaccination against it has managed to significantly reduce the incidence of the disease, it still remains a global presence.

Recent coverage in the mainstream media and from anti-vaccine proponents has suggested that the whooping cough bacterium has evolved around the current acellular vaccine. Such reports occurred following publication of a paper attributing over 80% of Australian cases to a new strain apparently not well covered by the vaccine.

This review analyses these claims. Careful examination of the current literature indicates that while the bacterium’s genome does appear to have changed in response to…

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