The anti-vaccination lobby’s long history

Hat tip to @BadScienceWatch.

From Jenner to Wakefield: The long shadow of the anti-vaccination movement


From YouTube Description:

In 1998 a medical furore broke out when The Lancet published an article by Andrew Wakefield questioning the benefits of the MMR vaccination which was being given unquestioningly to children throughout the UK.

Coming 202 years after the first vaccination by Edward Jenner, which led to the eradication of smallpox throughout the world, this recent incident is only the latest in a long history of questioning the benefits of vaccination.

From early irrational fears born of outdated medical understanding through to the latest medical research and findings, Professor Gareth Williams traces the history of the anti-vaccination movement and its long tail, reviewing the social settings in which the fears were found and offering a balanced assessment of vaccination as we find it today.

The transcript and downloadable versions of the lecture are available from the on the Gresham College website:
http://www.gresham.ac.uk/lectures-and…

Gresham College has been giving free public lectures since 1597. This tradition continues today with all of our five or so public lectures a week being made available for free download from our website.
http://www.gresham.ac.uk

Dorey and Dingle’s Vaccine-Autism Doppelgänger

Back on January 15th Meryl Dorey offered a rather messy tweet designed to sustain her fictitious claim that all vaccines are causally linked to autism.

Dorey_Jan15

I say “messy” because the January 14th Huffington Post article linked to, refers to the Vaccine Compensation Injury Program Court, compensating children that the ‘Post author wrongly insists have autism. Yet suppose this author – anti-vaccine terror-tattler David Kirby – was correct. We are still left with compensation awarded to children with autism. Not because of their autism.

Thus Dorey’s misleading query, “… how many more do we need b4 govt admits vaccines cause autism?”, is rather scurrilous. And that’s only if Kirby’s attempt to mislead the reader is based in fact. As it turns out the heading Vaccine Court Awards Millions to Two Children With Autism does not describe the events as they occurred.

In the case of Ryan Mojabi, on page 2 of the Court of Federal Claims Decision Awarding Damages document one reads:

On June 9, 2011, respondent filed a supplemental report pursuant to Vaccine Rule 4(c) stating it was respondent’s view that Ryan suffered a Table injury under the Vaccine Act – namely, an encephalitis within five to fifteen days following receipt of the December 19, 2003 MMR vaccine… and that this case is appropriate for compensation under the terms of the Vaccine Program.

That’s clear. Encephalitis, which is a Table injury under the Vaccine act.

Still, referring to Ryan the family had blamed all vaccines administered between March 25th 2003 to February 22nd 2005 as collectively causing “a severe and debilitating injury to his brain, described as Autism Spectrum Disorder”. Without picking over every detail there is a lack of agreement on exactly when and how persistently ill Ryan became. The family had travelled overseas and whilst the totality of doctor’s visits falls well short of that expected for a child as ill as Ryan’s parents allege, evidence was provided that he had presented with fever and rash in Tehran on January 6th 2004.

In August 2007 Ryan’s parents testified he had (post vaccination) experienced screaming, lethargy, floppiness, fever and shaking hands in 2003, just prior to travelling overseas. Ryan’s doctor has no evidence nor record of these events being reported as claimed. Nor that he had agreed to an overseas trip for Ryan whilst he was in that condition.

On page 15 of an earlier court document, Revised Ruling Regarding Factual Finding (May 2009) Ryan’s performance under Checklist for Autism in Toddlers [CHAT] on two dates well past his MMR vaccination, is discussed.

On May 10, 2004, at Ryan’s sixteen month well-child visit, Dr. Armstrong completed a Checklist for Autism in Toddlers (CHAT) screen. Ps’ Ex. 4 At 25. That CHAT screen indicated that Ryan was interested in other children, pretend play, peek-a-boo, points with index finger, makes eye contact, and brings object for show. On January 25, 2005, Dr. Armstrong examined Ryan for his twenty-four month well-baby check. Ps’ Ex. 4 at 31. During the visit, Dr. Armstrong conducted another CHAT screen, and again Ryan positively performed each of the listed behaviors.

The second case involves Emily Lowrie. Emily has a diagnosis of Pervasive Developmental Disorder – not otherwise specified and seizure disorder. PDD is not autism, but may be referred to as “atypical autism”. It is a form of ASD. According to Australia’s Raising Children’s Network, symptoms are “usually fewer or less pronounced” than with Autistic disorder or Asperger’s syndrome. There is evidence that Emily did develop a Table injury close to the time of vaccination. Yet there is no evidence that autism resulted and Kirby’s claim is simply false.

The vaccines-cause-autism devotees excel in labeling PDD-NOS as “autism” and often flesh out large samples by including “autistic like symptoms” where clear diagnoses of encephalitis and encephalopathy exist. As it happens Kirby runs off the tried and true Bailey Banks case. Bailey was diagnosed with PDD – a class of conditions to which autism belongs. Meryl Dorey misled her audience at the Woodford Folk Festival by fudging such diagnoses and for good measure plagiarising part of the Banks’ final ruling document. She added “[Autism]” to misrepresent PDD after lifting a quote directly from page 17 of the Banks v. HHS case file.

Other stunners exploiting the “autism-like” symptoms include the Pace Law School student debacle orchestrated by Mary Holland. This motivated Dorey to inform a commercial radio audience “hundreds, possibly thousands of families had been compensated”, as a result of vaccines causing autism. You can chase more on it up here.

Kirby also mentions Hannah Poling as though it is a foregone conclusion she developed autism from vaccination. Hannah’s mitochondrial enzymatic deficit and many environmental factors may trigger the encephalopathy she was compensated for. Many children with her mitochondrial condition develop encephalopathy in the first two years of life. As is often the case when science meets law, evidence is challenged by other dynamics. In this case it was the tireless efforts of her parents.

Jon Poling a neurologist and his wife Terry Poling a nurse and lawyer unfortunately refer to their victory as a “landmark” in vaccine-autism compensation. Little wonder certain key documents now remain under seal in other cases, providing conspiracy fodder for the likes of Kirby.

Some of Kirby’s conspiratorial nonsense includes:

Some observers will say the vaccine-induced encephalopathy (brain disease) documented in both children is unrelated to their autism spectrum disorder (ASD). Others will say there is plenty of evidence to suggest otherwise. […] Whether HHS agreed with Ryan’s parents that his vaccine-induced brain disease led to ASD is unknown. The concession document is under seal.

It looked like the family had a weak case.

But then something changed.

In October, 2010, Ryan’s attorney filed four new exhibits (under seal) and proposed amending the court’s “findings of fact.” […]

Readers are supposed to conclude something dark and dastardly has occurred. Never mind Kirby actually repeats the fact that there is no evidence for his supposition.

Orac does a great job of knocking Kirby off and quite rightly refers to one jaw-dropper as “Grade A conspiracy mongering”. We’re asked to accept that Emily’s mother, Jillian Moller, is relaying a factual account when we read:

After the ASD diagnosis, the judge reportedly became convinced that Emily would prevail. “My attorney said she was angry, she felt forced into a corner with no choice but to find for us,” Moller said. “She said, ‘Emily has autism, and I don’t want to give other families who filed autism claims any hope.'”

One doesn’t expect any different from an attempt to amplify the long disproved, non-existent link between vaccines and autism from Meryl Dorey. Yet even amongst our most radical evidence denialists and defenders of alternatives to medicine, should not a PhD give pause to consult the facts? To at least, say, delineate between autism and PDD-NOS. Maintain a bit of fidelissima integritatum with one’s readers perchance?

Not for Dr. Peter Dingle it seems. He’d tweeted recently and placed the same conclusion in the lap of “the independent court”. Could it be? A fortnight later than Ms. Dorey’s effort the event was repeating itself? Surely there was a new story. But no. Doc Dingle had availed himself of Kirby’s caper and leaped to the same conclusion. With exactly the same HuffPost tweet. It was identical. It was… a dopellgänger!

Dingle_Jan29

On a serious note, the damage done by individuals such as Dingle perpetrating this myth is far from insignificant. It ignores the truth and does little for those in genuine need of compensation.

It is right and proper that children injured by vaccines are compensated. With brain damage rates of one in one million related to MMR of course we will see these cases. Yet for cases of measles infection the rates are one in one thousand. Of course there is no anti-vaccine compensation program.

Although differences are subtle, denying the evidence and etiology peculiar to vaccine injury and disability helps no-one. If we consider similar patients all presenting with Acquired Brain Injury, virtually identical symptoms yet various etiology it is easier to see the importance of this. Road trauma, stroke, near drowning, boxing or other sporting injury may all present identical motor, speech, memory and other lifestyle challenges. False links driven by ideology would rightly appear bizarre.

What we do know in these VCIP cases is that several million dollars have been awarded to each child.

Yet it was not because vaccines cause autism.

GAVI Alliance: the success continues

One of the most impressive speakers I’ve had the pleasure of hearing is Seth Berkley.

Seth is CEO of the GAVI Alliance. The incredible life-saving machine known as “the GAVI model” has prevented over 5 1/2 million future deaths through the immunisation of 370* million children since 2000.

* – May 2012 projection

GAVI’s mission encompasses a bold, compassionate vision, effective strategies, education and commitment. GAVI has pulled together very specific dynamics of international development, finance organisations, donor governments, the pharmaceutical industry, developing countries, WHO, UNICEF, Bill and Melinda Gates Foundation and the World Bank into a single “decision-making body”.

This uniquely complex approach allows the central part of the GAVI vision to be realised:

Saving children’s lives and protecting people’s health by increasing access to immunisation in poor countries

GAVI has every right to be proud that its model has permitted “a single-minded focus to the urgent task of closing three critical gaps in the provision of vaccines”:

  • between children for whom immunisation is a given and the 19 million children worldwide with no access to vaccines;
  • between the introduction of a new vaccine in rich countries and the average 10-15 years required for the same vaccine to reach low-income countries;
  • between the need for new vaccines in developing countries and the lack of research and funds to provide them.

In 2009 UNICEF reported that more children are being immunised than ever before and this is “directly attributable” to the success of the GAVI model. With the support of GAVI, 18 developing nations had begun to introduce the pneumococcal vaccine by mid-2012. Better still this vaccine will soon be part of routine programmes in half of GAVI-eligible countries. Pneumonia is the cause of 18% of child deaths in developing nations.

Another 18% of deaths in children is due to diarrhoea, primarily caused by rotavirus. By the end of last year 20 GAVI-eligible countries had been approved for support in implementing vaccines against rotavirus. It’s wonderful that by the end of last month Sudan was joined by Rwanda, Malawi and Ghana as the first African nations to see GAVI help roll out rotavirus vaccines.

Consider for a moment, Ghana. The first GAVI supported country to introduce both rotavirus and pneumococcal vaccines together, Ghana can now directly address and prevent the cause of 36% of childhood fatality.

GAVI have excelled in meeting demand. In the middle of 2011 more applications than ever before were made to GAVI for both new and underused vaccines. Late last year two thirds of GAVI programmes met demand for both rotavirus vaccine (representing a nine fold increase) and pneumococcal (representing a doubling of demand). The diagram below indicates how GAVI commits funds to specific purposes.

Meanwhile in the developed world we continue to enjoy the luxury of faux “vaccine injuries” and other hoax reasons proffered as cause to deny children immunisation. This itself is an indicator of, and direct result from, the success of mass immunisation. Vaccine induced immunity and herd immunity protecting the unvaccinated, remains out of reach in poorer nations wherein one child dies from a vaccine preventable disease every 20 seconds.

Where vaccination regimes have been successful such tragic suffering is forgotten. Indeed, subtracting the impact of vaccine denial, there’s virtually no evidence of it in our midst. But this does not mean we may have cause for complacency – no matter how strong both specific and herd immunity might be. Influenza pandemics remain a serious threat to humanity. It’s been estimated that the likelihood of such a Massively Fatal Discontinuity, able to kill up to 100 million people in the next 50 years, is 100%.

Back in February 2010 Seth Berkley looked at the importance of vaccines to human health, and our survival.

Wise words.

HIV and flu — the vaccine strategy (TED Talks)


Source – GAVI


A fact sheet should have facts

There are only two organs in the human body where we know the cause of cancers that effect them.

One is the liver, which has shown a definite link between the hepatitis B [HBV] virus and liver cancer. The other is the cervix with an irrefutable link between human papillomavirus [HPV] and cervical cancer. As we have vaccines to prevent infection with these viruses, HBV derived liver cancer and cervical cancer may thus be considered “preventable cancers”.

In the case of the HPV vaccine, anti-vaccine lobbyist and University of Wollongong student Judy Wilyman continues to deny its success. A cervical cancer “fact sheet” on her web site contains irrelevant or misleading snippets of misinformation. Designed to create a fiction, the item is anything but a “fact sheet”.

It begins with the confusing claim that the HPV vaccine Gardasil was not trialled against cervical cancer. Rather it was trialled in 16-26 year old women against pre-cancerous lesions. Wilyman criticises the age group because women therein rarely present with cervical cancer. She criticises the focus on pre-cancerous lesions because most do not lead to cervical cancer.

Later Wilyman observes that cervical cancer takes 8-25 years to develop answering her own concern about lower rates of cervical cancer in the sample group. With respect to pre-cancerous lesions her thinking is disturbing. Cervical cancer develops from these lesions and the trial demonstrated a reduction in development by almost half.  Unsurprisingly Wilyman then notes the death rate is 1.9/100,000 – “a very low risk to Australian women”.

We’re informed, “there are more than 15 high risk strains associated with cancer not covered by the vaccine”. Strange. Now Judy has a sudden concern for cancers caused by HPV? No. She’s omitted that 70% of cancers are caused by HPV strains 16 and 18 and that Gardasil also targets HPV 6 and 11, responsible for 90% of genital warts. The vaccine is almost 100% effective against these strains.

We read that, “the duration of this vaccine is unknown as it has only been tested in adults for 3-4 years”. I’m sure Judy means the duration of immunity. Perhaps she overlooked the role of antibody response and concentration in predicting immunity. The reality is that whilst research is ongoing, close to 100% protection remained after five years. Protection shows no signs of weakening. Whilst the need for a booster has not yet been established it appears to be unlikely that it will.

  • “We don’t know how long vaccine protection will last”, is regarded as a Myth by the Australian Cancer Council.

Further criticism of trials include the observation that, “in young women pre-cancerous lesions have a high clearance rate and do not always lead to cancer”. This completely ignores the necessity to vaccinate before the onset of sexual activity and exposure to wild HPV. Vaccines are preventative, not curative. It is a most strange complaint from a “PhD candidate”, failing to understand the very aim of the trial.

Five separate references to trials being conducted and funded by drug companies are listed. This assumed conspiracy is frequently cited by Wilyman in regard to all vaccines without making any links to, or cogent arguments about, inefficacy or unsound trials. Conflict of interest and the influence of drug companies should be, and is, taken very seriously by relevant sections of the scientific community. But accusatory assumption without evidence is unacceptable.

Wilyman seems to deliberately mislead by documenting as a “concern” that 94 deaths and 21,635 adverse reactions are associated with Gardasil. Citing anti-vaccine lobby group S.A.N.E. she then notes that only 10% of reactions are picked up by the passive surveillance systems that produced those figures. What does this mean?

When authorities talk of under-reporting in passive surveillance they refer to minor events – soreness, redness, swelling, a bit queasy post influenza jab etc. These are so minor as to be inconsequential to the recipient, thus never reach the vaccine provider for reporting to the system. Her intent is to insinuate close to 950 deaths and well over 200,000 adverse reactions are possibly/probably associated with or causally linked to Gardasil.

Of reactions that are reported there is no evidence of any link. Great efforts are made to convey causality has not been demonstrated. All that’s known is that the event occurred sometime after vaccination. Also, reports remain on the database no matter how unlikely or ridiculous. Despite easy access on how to avoid the trap Judy Wilyman has set, she has chosen to obfuscate the reality.

These reporting systems exist to highlight trends from which likely adverse reactions are chosen for follow up study. It’s the findings of these studies that provide any evidence backed conclusions on adverse reactions. When links are shown to not exist the reports still remain on the database.

We may confidently dismiss her figures of 94 deaths and 21,635 adverse reactions. Conclusions cannot be drawn from unverified reports.

The “fact sheet” also includes claims that the aluminium adjuvant is, “known to cause allergies/anaphylaxis and auto-immune reactions in humans”. This claim has been criticised with regard to many vaccines. With 65 million doses of HPV vaccine given safely in over 100 countries, rates of serious allergic reactions are being recorded at about three per one million doses.

Nonetheless a paper cited by Wilyman does speculate on a possible role of adjuvants in auto-immune disorders. It must be stressed that in this review vaccine adjuvants alone have not been identified, nor is there any robust research behind the proposition. Possibly, Wilyman has not read the material.

Certainly, Judy Wilyman selectively cites trial methodology. Ignoring use of saline placebo in safety trials [page 4], she zeros in on AAHS because it’s “not a true placebo used to test safety”:

The manufacturer funded clinical trials used the adjuvant, aluminium hydroxyphosphate sulphate as the placebo in the unvaccinated group: a chemical known to be linked to adverse events including autoimmune diseases

One cannot stress enough that aluminium hydroxyphosphate sulphate is not “known to be linked” to ADRs or autoimmune disease. Five months later the authors write in The Rheumatologist:

Taking it all together, it seems that enigmatic but nevertheless common and often disabling complaints can coincide in many individuals diagnosed with siliconosis, MMF, GWS, or postvaccination events […]

Moreover, genetic links observed in animal models, and in the human disease MMF, bring about the notion that the adjuvant effect promotes the appearance of an adjuvant disease in subjects who are genetically susceptible or in those who encounter an additional trigger…

At best this is speculation. At worst the authors are attempting to coin a new syndrome based on review and suggest it be used to label challenging diagnoses. Examining their contention nonetheless, it’s clear they refer to a rare and individualised pathology.

Wilyman also cites anti-vaccine lobby group Immunisation Awareness Society, N.Z. in claiming that juvenile, rheumatoid and osteoarthritis are caused by Gardasil. As recently as January this year another study found no evidence of this.

  • “The vaccine has serious side effects that aren’t being reported” is considered a Myth by the Australian Cancer Council.

No attempt is made to mention the Australian HPV Register and its role in ongoing assessment. A large portion of Wilyman’s so-called fact sheet seeks to demote the risk of HPV infection, relegating it to developing nations or to a small promiscuous section of our community.

The rest seeks to spook readers into feeling that 200 cervical cancer deaths annually and unnecessary genital warts is acceptable collateral damage.

It is a biased and misleading document.

Hepatitis B vaccine: Preventing cancer, except for when it’s not actually given…

Essential reading from @kill3rTcell.

An excellent review of the preventative impact on liver cancer provided by the full sequence of the Hepatitis B vaccine schedule. Includes a thorough deconstruction of the disinformation frequently pushed by Australia’s Anti-Vaccination Network that the vaccine is ineffective in this regard or (no surprise) is the “cause” of increasing hepatitis B infection.

—————————————————

The comment cited below;

…however just last night Dorey posted the following comment on the AVN page:

HBV_post_lymphosite_post

The chart cited below;

lymphosite_post2

Right now I’m going to focus on the claim of increasing liver cancer rates thanks to Hep B vaccination.

kill3rtcell's avatarThe LymphoSite

One of the commentors over on the Australian Anti-Vaccination Network’s facebook page challenged the group’s president – Meryl Dorey – to comment on a hypothetical scenario as a way of discussing the utility of vaccination against Hepatitis B (Hep B). A conversation ensued and commentor’s question was never answered, however just last night Dorey posted the following comment on the AVN page:

…with this chart of liver cancer incidence in the United Kingdom:

Right now I’m going to focus on the claim of increasing liver cancer rates thanks to Hep B vaccination.

But first the rationale behind using the Hep B vaccine to prevent liver cancer:

  • Hepatitis B is a virus that chronically infects liver cells.
  • This chronic infection naturally leads to prolonged inflammation.
  • A continual inflammatory state is conducive to cancer formation.

(The virus also seems to be able to integrate its DNA into host cells to cause…

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